Saccharopine
- Saccharopine
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Saccharopine |
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![Saccharopine.svg](/pictures/frwiki/49/175px-Saccharopine.svg.png)
Structure de la L-saccharopine |
Général |
Nom IUPAC |
acide (2S)-2-[[(5S)-5-amino-5-carboxypentyl]amino]pentanedioïque |
Synonymes |
acide N-(5-amino-5-carboxypentyl)-glutamique |
No CAS |
997-68-2 |
PubChem |
160556 |
ChEBI |
16927 |
SMILES |
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InChI |
Std. InChI : Vue 3D
InChI= 1S/ C11H20N2O6/ c12- 7( 10( 16) 17) 3- 1- 2- 6- 13- 8( 11( 18) 19) 4- 5- 9( 14) 15/ h7- 8, 13H, 1- 6, 12H2,( H, 14, 15)( H, 16, 17)( H, 18, 19)/ t7-, 8-/ m0/ s1
Std. InChIKey :
ZDGJAHTZVHVLOT- YUMQZZPRSA- N
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Propriétés chimiques |
Formule brute |
C11H20N2O6 [Isomères]
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Masse molaire[1] |
276,2863 ± 0,0124 g·mol-1
C 47,82 %, H 7,3 %, N 10,14 %, O 34,75 %,
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Unités du SI & CNTP, sauf indication contraire.
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La saccharopine est un composé chimique de formule HOOC–HN(NH2)–CH2–CH2–NH–CH(COOH)–CH2–CH2–COOH. C'est un acide tricarboxylique résultant de la condensation d'une molécule de lysine avec une molécule d'α-cétoglutarate par une saccharopine déshydrogénase (EC 1.5.1.7, EC 1.5.1.8, EC 1.5.1.9 ou EC 1.5.1.10). Il s'agit de la première étape de la dégration de la lysine chez les mammifères et les plantes supérieures.
La saccharopine est ensuite convertie en allysine, ou acide 2-aminoadipique-6-semialdéhyde, également par une saccharopine déshydrogénase :
- lysine + α-cétoglutarate
saccharopine
glutamate + allysine.
Notes et références
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Contenu soumis à la licence CC-BY-SA. Source : Article Saccharopine de Wikipédia en français (auteurs)
Regardez d'autres dictionnaires:
Saccharopine — Chembox new ImageFile=Saccharopine.gif ImageSize=125px IUPACName=2 [(5 amino 5 carboxy pentyl) amino] pentanedioic acid OtherNames= Section1= Chembox Identifiers CASNo=997 68 2 PubChem=1087 SMILES=C(CCNC(CCC(=O)O)C(=O)O)CC(C(=O)O)N… … Wikipedia
Saccharopine dehydrogenase — protein Name=saccharopine dehydrogenase (putative) caption= width= HGNCid=24275 Symbol=SCCPDH AltSymbols= EntrezGene=51097 OMIM= RefSeq=NM 016002 UniProt=Q8NBX0 PDB= ECnumber= Chromosome=1 Arm=q Band=44 LocusSupplementaryData=Saccharopine… … Wikipedia
Saccharopine dehydrogenase (NAD+, L-glutamate-forming) — In enzymology, a saccharopine dehydrogenase (NAD+, L glutamate forming) (EC number|1.5.1.9) is an enzyme that catalyzes the chemical reaction:N6 (L 1,3 dicarboxypropyl) L lysine + NAD+ + H2O ightleftharpoons L glutamate + 2 aminoadipate 6… … Wikipedia
Saccharopine dehydrogenase (NADP+, L-glutamate-forming) — In enzymology, a saccharopine dehydrogenase (NADP+, L glutamate forming) (EC number|1.5.1.10) is an enzyme that catalyzes the chemical reaction:N6 (L 1,3 dicarboxypropyl) L lysine + NADP+ + H2O ightleftharpoons L glutamate + L 2 aminoadipate 6… … Wikipedia
Saccharopine dehydrogenase (NAD+, L-lysine-forming) — In enzymology, a saccharopine dehydrogenase (NAD+, L lysine forming) (EC number|1.5.1.7) is an enzyme that catalyzes the chemical reaction:N6 (L 1,3 dicarboxypropyl) L lysine + NAD+ + H2O ightleftharpoons L lysine + 2 oxoglutarate + NADH + H+The… … Wikipedia
Saccharopine dehydrogenase (NADP+, L-lysine-forming) — In enzymology, a saccharopine dehydrogenase (NADP+, L lysine forming) (EC number|1.5.1.8) is an enzyme that catalyzes the chemical reaction:N6 (L 1,3 dicarboxypropyl) L lysine + NADP+ + H2O ightleftharpoons L lysine + 2 oxoglutarate + NADPH +… … Wikipedia
saccharopine dehydrogenase — sac·cha·ro·pine de·hy·dro·gen·ase (sakґə ro pēn″ de hiґdro jən ās) an enzyme activity that catalyzes oxidative cleavage of saccharopine to form α aminoadipate semialdehyde and glutamate, using NAD+ as an electron… … Medical dictionary
saccharopine dehydrogenase (NAD+ L-glutamate-forming) — sac·cha·ro·pine de·hy·dro·gen·ase (NAD+, L glu·ta·mate form·ing) (sakґə ro pēn″ de hiґdro jən ās glooґtə māt formґing) [EC 1.5.1.9] official nomenclature for saccharopine dehydrogenase … Medical dictionary
saccharopine — A derivative of α ketoglutarate and l lysine that is an intermediate in l lysine catabolism; elevated in cases of saccharopinuria. s. dehydrogenase two enzymes that are used in the pathway of l lysine catabolism; the first isoform catalyzes the… … Medical dictionary
saccharopine dehydrogenase (NADP+ L-lysine-forming) — sac·cha·ro·pine de·hy·dro·gen·ase (NADP+, L ly·sine form·ing) (sakґə ro pēn″ de hiґdro jən ās liґsēn formґing) [EC 1.5.1.8] official nomenclature for lysine ketoglutarate reductase … Medical dictionary