Perphénazine
- Perphénazine
-
| Perphénazine |
 |
| Général |
| Nom IUPAC |
2-[4-[3-(2-chloro-10H-phenothiazin-10-yl) propyl]piperazin-1-yl]ethanol |
| No CAS |
58-39-9 |
| No EINECS |
200-381-5 |
| Code ATC |
N05AB03 |
| DrugBank |
DB00850 |
| PubChem |
4748 |
| ChEBI |
8028 |
| SMILES |
|
| InChI |
InChI : Vue 3D
InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
|
| Propriétés chimiques |
| Formule brute |
C21H26ClN3OS [Isomères]
|
| Masse molaire[2] |
403,969 ± 0,027 g·mol-1
C 62,44 %, H 6,49 %, Cl 8,78 %, N 10,4 %, O 3,96 %, S 7,94 %,
|
| pKa |
7.94 [1] |
| Propriétés physiques |
| T° fusion |
97 °C [1] |
| Solubilité |
28,3 mg·l-1 (eau,24 °C) [1] |
| Écotoxicologie |
| DL50 |
120 mg·kg-1 (souris, oral)
19 mg·kg-1 (souris, i.v.)
80 mg·kg-1 (souris, s.c.)
64 mg·kg-1 (souris, i.p.) [1] |
| LogP |
4,2 [1] |
| Données pharmacocinétiques |
| Biodisponibilité |
40 % (orale) |
| Métabolisme |
hépatique |
| Demi-vie d’élim. |
8-12 (jusqu'à 20) heures |
| Excrétion |
biliaire |
|
Unités du SI & CNTP, sauf indication contraire.
|
La perphénazine (Trilifon) est un antipsychotique typique, utilisé depuis des décennies.
Voir aussi
Articles connexes
Liens externes
Notes et références
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Contenu soumis à la licence CC-BY-SA. Source : Article Perphénazine de Wikipédia en français (auteurs)
Regardez d'autres dictionnaires:
Perphenazine — Systematic (IUPAC) name 2 [4 [3 (2 chloro 10H phenothiazin 10 yl) propyl]piperazin 1 yl]ethanol Clinical data AHFS/Drugs.com … Wikipedia
perphenazine — noun Etymology: blend of piperazine and phen Date: 1957 a phenothiazine tranquilizer C21H26ClN3OS that is used especially to control psychotic symptoms (as anxiety and agitation) … New Collegiate Dictionary
perphenazine — /peuhr fen euh zeen , zin/, n. Pharm. a crystalline, water insoluble powder, C21H26ClN3OS, used chiefly as a tranquilizer and in the treatment of intractable hiccoughs and nausea and vomiting. [1955 60; PER + PHEN(OTHI)AZINE] * * * … Universalium
perphenazine — noun A potent anti psychotic drug … Wiktionary
perphenazine — An antipsychotic of the phenothiazine type. * * * per·phen·a·zine (.)pər fen ə .zēn n a phenothiazine tranquilizer C21H26ClN3OS used esp. to control symptoms (as anxiety, agitation, and delusions) of psychotic conditions * * * n. a phenothiazine… … Medical dictionary
perphenazine — per·phe·na·zine … English syllables
perphenazine — n. a phenothiazine antipsychotic drug used to treat schizophrenia, mania, anxiety, and severe agitation and to prevent and treat severe nausea and vomiting. It is administered by mouth; side effects are similar to those of fluphenazine. Trade… … The new mediacal dictionary
perphenazine — per•phen•a•zine [[t]pərˈfɛn əˌzin, zɪn[/t]] n. pha a crystalline, water insoluble powder, C21H26ClN3Oused as a tranquilizer and in treating intractable hiccups and nausea • Etymology: 1955–60; per +phen (othi) azine … From formal English to slang
perphenazine — noun tranquilizer and antidepressant (trade name Triavil) sometimes used as an antiemetic for adults • Syn: ↑Triavil • Usage Domain: ↑trade name (for: ↑Triavil) • Hypernyms: ↑minor tranquilizer, ↑ … Useful english dictionary
58-39-9 — Perphénazine Perphénazine Général Nom IUPAC 2 [4 [3 (2 chloro 10H phenothiazin 10 yl) propyl]piperazin 1 yl]ethanol … Wikipédia en Français
