Trifluopérazine
- Trifluopérazine
-
| Trifluopérazine |
 |
| Général |
| Nom IUPAC |
10-[3-(4-méthylpipérazin-1-yl)propyl]-2-(trifluorométhyl)-10H-phénothiazine |
| No CAS |
117-89-5 |
| No EINECS |
204-219-4 |
| Code ATC |
N05AB06 |
| DrugBank |
DB00831 |
| PubChem |
5566 |
| ChEBI |
45951 |
| SMILES |
CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F
PubChem, Vue 3D
|
| InChI |
InChI : Vue 3D
InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
|
| Propriétés chimiques |
| Formule brute |
C21H24F3N3S [Isomères]
|
| Masse molaire[1] |
407,496 ± 0,024 g·mol-1
C 61,9 %, H 5,94 %, F 13,99 %, N 10,31 %, S 7,87 %,
|
| Propriétés physiques |
| Solubilité |
12,2 mg·l-1 (eau,24 °C) [2] |
| Écotoxicologie |
| DL50 |
1,35 g·kg-1 (souris, oral)
29 mg·kg-1 (souris, i.v.)
120 mg·kg-1 (souris, i.p.) [2] |
| LogP |
5,03 [2] |
| Données pharmacocinétiques |
| Métabolisme |
hépatique |
| Demi-vie d’élim. |
10-20 heures |
|
Unités du SI & CNTP, sauf indication contraire.
|
La trifluopérazine (Terfluzine) est un antipsychotique typique de la classe des phénothiazines.
Notes et références
Liens externes
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2010.
Contenu soumis à la licence CC-BY-SA. Source : Article Trifluopérazine de Wikipédia en français (auteurs)
Regardez d'autres dictionnaires:
Trifluoperazine — Systematic (IUPAC) name 10 [3 (4 methylpiperazin 1 yl)propyl] 2 (trifluoromethyl) 10H phenothiazine Clinical data AHFS/ … Wikipedia
trifluoperazine — noun Etymology: tri + fluor + piperazine Date: circa 1957 a phenothiazine tranquilizer C21H24F3N3S chiefly used to treat psychotic conditions and especially schizophrenia … New Collegiate Dictionary
trifluoperazine — (= TFP; trifluperazine; Stellazine) Antipsychotic drug that inhibits calmodulin at levels just below those at which it kills cells … Dictionary of molecular biology
trifluoperazine — /truy flooh euh per euh zeen /, n. Pharm. a compound, C21H24F3N3S, used as an antipsychotic. [1955 60; TRI + FLUO + (PI)PERAZINE] * * * … Universalium
trifluoperazine — noun An antipsychotic drug of the phenothiazine group … Wiktionary
trifluoperazine — tri·fluo·per·a·zine .trī .flü ō per ə .zēn, zən n a phenothiazine tranquilizer C21H24F3N3S used esp. to treat psychotic conditions and esp. schizophrenia see STELAZINE * * * n. an antipsychotic drug (a phenothiazine) with uses and effects similar … Medical dictionary
trifluoperazine — n. chemical compound used as a sedative … English contemporary dictionary
trifluoperazine — tri·fluo·per·a·zine … English syllables
trifluoperazine — n. an antipsychotic drug (a phenothiazine) used in the treatment of schizophrenia and other psychoses, severe anxiety, and severe nausea and vomiting. It is taken by mouth; common side effects include drowsiness, dryness of mouth, dizziness,… … The new mediacal dictionary
trifluoperazine — tri•flu•o•per•a•zine [[t]traɪˌflu əˈpɛr əˌzin[/t]] n. pha a compound, C21H24F3N3used as an antipsychotic drug • Etymology: 1955–60; tri +fluo , var. of fluoro + (pi) perazine … From formal English to slang
