Thioridazine
- Thioridazine
-
| Thioridazine |
 |
| Général |
| Nom IUPAC |
10-{2-[(RS)-1-méthylpipéridin-2-yl]éthyl}-2-méthylsulfanyl-phénothiazine |
| No CAS |
50-52-2 |
| No EINECS |
200-044-2 |
| Code ATC |
N05AC02 |
| DrugBank |
APRD00596 |
| PubChem |
5452 |
| SMILES |
|
| InChI |
InChI : Vue 3D
InChI=1/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
|
| Propriétés chimiques |
| Formule brute |
C21H26N2S2 [Isomères]
|
| Masse molaire[1] |
370,575 ± 0,029 g·mol-1
C 68,06 %, H 7,07 %, N 7,56 %, S 17,31 %,
|
| Propriétés physiques |
| T° fusion |
73 °C |
| Pression de vapeur saturante |
1,42×10-9 mmHg à 25 °C |
| Écotoxicologie |
| DL50 |
(souris, oral, 385 mg·kg-1) |
| Données pharmacocinétiques |
| Liaison protéique |
95% |
| Métabolisme |
hépatique |
| Demi-vie d’élim. |
7–13 heures (jusqu'à 20 heures) |
| Excrétion |
fèces |
| Considérations thérapeutiques |
| Voie d’administration |
orale |
|
Unités du SI & CNTP, sauf indication contraire.
|
La thioridazine (Melleril) est un antipsychotique typique.
Notes et références
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Contenu soumis à la licence CC-BY-SA. Source : Article Thioridazine de Wikipédia en français (auteurs)
Regardez d'autres dictionnaires:
Thioridazine — Not to be confused with Thorazine. Thioridazine Systematic (IUPAC) name … Wikipedia
thioridazine hydrochloride — An antipsychotic with action similar to that of chlorpromazine but with relatively stronger anticholinergic effects. * * * [USP] the monohydrochloride salt of thioridazine, having the same actions and uses as the base; administered orally … Medical dictionary
thioridazine — noun Etymology: thi + piperidine + phenothiazine Date: 1959 a phenothiazine tranquilizer C21H26N2S2 used in the form of its hydrochloride for relief of anxiety states and in the treatment of psychotic disorders and severe childhood behavioral… … New Collegiate Dictionary
thioridazine — /thuy euh rid euh zeen , zin/, n. Pharm. a phenothiazine, C21H26N2S2, used as an antipsychotic chiefly in the treatment of acute psychoses and schizophrenia. [1955 60; THIO + (PIPE)RID(INE) + AZINE] * * * … Universalium
thioridazine — noun An antipsychotic drug used in the treatment of anxiety, depression and autism … Wiktionary
thioridazine — thio·rid·a·zine .thī ə rid ə .zēn, zən n a phenothiazine tranquilizer used in the form of its hydrochloride C21H26N2S2·HCl for relief of anxiety states and in the treatment of psychotic disorders and severe childhood behavioral problems see… … Medical dictionary
thioridazine — thi·o·rid·a·zine … English syllables
thioridazine — noun a tranquilizer (trade name Mellaril) used to treat schizophrenia and other psychotic disorders • Syn: ↑Mellaril • Usage Domain: ↑trade name (for: ↑Mellaril) • Hypernyms: ↑ … Useful english dictionary
50-52-2 — Thioridazine Thioridazine Général Nom IUPAC 10 {2 [(RS) 1 Methylpiperidin 2 yl]ethyl} 2 methylsulfanyl phenothiazine … Wikipédia en Français
C21H26N2S2 — Thioridazine Thioridazine Général Nom IUPAC 10 {2 [(RS) 1 Methylpiperidin 2 yl]ethyl} 2 methylsulfanyl phenothiazine … Wikipédia en Français
