Fluphénazine
- Fluphénazine
-
| Fluphénazine |
 |
| Général |
| Nom IUPAC |
2-[4-[3-[2-(trifluoromethyl)-
10H-phenothiazin-10-yl]propyl]-
piperazin-1-yl]ethanol |
| No CAS |
69-23-8 |
| No EINECS |
200-702-9 |
| Code ATC |
N05AB02 |
| DrugBank |
APRD00633 |
| PubChem |
3372 |
| Propriétés chimiques |
| Formule brute |
C22H26F3N3OS
|
| Masse molaire[1] |
437,522 ± 0,025 g·mol-1
C 60,39 %, H 5,99 %, F 13,03 %, N 9,6 %, O 3,66 %, S 7,33 %,
|
| Propriétés physiques |
| T° fusion |
<25 °C[2] |
| Pression de vapeur saturante |
1,02×10-12 mmHg à 25 °C[2] |
| Écotoxicologie |
| DL50 |
(souris, oral, 220 mg·kg-1)[2] |
| Données pharmacocinétiques |
| Biodisponibilité |
40 à 50% |
| Métabolisme |
hépatique |
| Demi-vie d’élim. |
15 à 30 heures |
| Excrétion |
bile et fèces |
| Considérations thérapeutiques |
| Voie d’administration |
orale[3], intramusculaire[3] |
|
Unités du SI & CNTP, sauf indication contraire.
|
La fluphénazine (Modecate, Moditen) est un antipsychotique typique.
Notes et références
Liens externes
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2010.
Contenu soumis à la licence CC-BY-SA. Source : Article Fluphénazine de Wikipédia en français (auteurs)
Regardez d'autres dictionnaires:
Fluphenazine — Systematic (IUPAC) name 2 [4 [3 [2 (trifluoromethyl) 10H phenothiazin 10 yl]propyl]piperazin 1 yl]ethanol Clinical data … Wikipedia
Fluphenazine — Fluphénazine Fluphénazine Général Nom IUPAC 2 [4 [3 [2 (trifluoromethyl) 10H phenothiazin 10 yl]propyl] piperazin 1 yl]ethanol … Wikipédia en Français
fluphenazine — A drug that is used to treat mental and emotional disorders and is being studied in the treatment of multiple myeloma. Fluphenazine may stop tumor growth by keeping myeloma cells from dividing and causing them to die. It is a type of… … English dictionary of cancer terms
fluphenazine hydrochloride — A drug that is used to treat mental and emotional disorders and is being studied in the treatment of multiple myeloma. Fluphenazine hydrochloride may stop tumor growth by keeping myeloma cells from dividing and causing them to die. It is a type… … English dictionary of cancer terms
fluphenazine decanoate — [USP] the decanoate ester of fluphenazine, having the same actions as the hydrochloride salt, but of longer duration; administered subcutaneously or intramuscularly in maintenance therapy for psychotic disorders … Medical dictionary
fluphenazine enanthate — [USP] the enanthate ester of fluphenazine, having the same uses as the hydrochloride salt, but of longer duration; administered intramuscularly and subcutaneously … Medical dictionary
fluphenazine hydrochloride — [USP] the dihydrochloride salt of fluphenazine, used as an antipsychotic; administered orally and intramuscularly … Medical dictionary
fluphenazine — noun Etymology: fluor + phenazine Date: 1959 a tranquilizer C22H26F3N3OS used especially in the form of its hydrochloride … New Collegiate Dictionary
fluphenazine — /flooh fen euh zeen /, n. Pharm. a potent tranquilizer, C22H26F3N3OS, derived from phenothiazine and used in various forms for the management of certain neurological or psychotic disorders and for short term treatment of acute anxiety. [1955 60;… … Universalium
fluphenazine — noun An antipsychotic drug used in the treatment of schizophrenia etc … Wiktionary
