Arsphenamine
- Arsphenamine
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Arsphénamine
| Arsphénamine |
 |
| Général |
| Synonymes |
Salvarsan
606 |
| No CAS |
139-93-5 (2HCl) |
| No EINECS |
205-386-6 |
| SMILES |
|
| InChI |
InChI=1/C12H12As2N2O2.2ClH/c15-9-5-7(1-3-11(9)17)13-14-8-2-4-12(18)10(16)6-8;;/h1-6,17-18H,15-16H2;2*1H
|
| Propriétés chimiques |
| Formule brute |
C12H14As2Cl2N2O2 [Isomères]
|
| Masse molaire |
439,001 g∙mol-1
C 32,83 %, H 3,21 %, As 34,13 %, Cl 16,15 %, N 6,38 %, O 7,29 %,
|
| Propriétés physiques |
| T° fusion |
190 °C (décomposition) |
|
Unités du SI & CNTP, sauf indication contraire.
|
L'arsphénamine a été découverte en 1908 par Sahachiro Hata dans le laboratoire de Paul Ehrlich. C'est un médicament composé d'arsenic, utilisé pour traiter la syphilis et la trypanosomiasis. Il s'agit du premier agent chemotherapeutique moderne.
L'arsphénamine est aussi connue sous le nom de Salvarsan (1910), ou de 606.
Portail de la pharmacie
Portail de la médecine
Portail de la chimie
Catégories : Composé de l'arsenic | Médicament | Aminobenzène | Phénol
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Arsphenamine — Arsphenamine, also known as Salvarsan and 606, is a drug that was used to treat syphilis and trypanosomiasis. It was the first modern chemotherapeutic agent.HistorySahachiro Hata discovered the anti syphilitic activity of this compound in 1908 in … Wikipedia
Arsphénamine — Général Nom IUPAC 2 amino 4 (3 amino 4 hydroxyphényl)arsanylidènearsanylphénol hydrochloride Synonymes … Wikipédia en Français
arsphenamine — [ärs fen′ə mēn΄, ärs fen′əmin΄] n. [ ARS(ENIC) + PHEN(YL) + AMINE] a yellowish arsenical powder, [OH·C6H3 (NH2·HCl)·As] 2, formerly used in treating syphilis … English World dictionary
arsphenamine — noun Etymology: International Scientific Vocabulary arsenic + phenamine Date: 1917 a light yellow toxic hygroscopic powder C12Cl2H14As2N2O2•2H2O formerly used in the treatment especially of syphilis and yaws … New Collegiate Dictionary
arsphenamine — /ahrs fen euh meen , min/, n. Pharm. a yellow, crystalline powder, C12H12N2O2As2·2HCl·2H2O, formerly used to treat diseases caused by spirochete organisms, esp. syphilis and trench mouth: first known as 606. [1915 20; ARS(ENIC) + PHEN(YL) +… … Universalium
arsphenamine — noun /ɑːsˈfɛnəmaɪn,ɑːsˈfɛnəmiːn/ A phenolic amine derivative of arsenic that was used to treat syphilis (under the trade name of Salvarsan) … Wiktionary
arsphenamine — Formerly used in the treatment of syphilis, yaws, and some other diseases of protozoan origin, after neutralization with NaOH. The synthesis of a. in 1907 and the demonstration of its usefulness as a therapeutic agent by Paul Ehrlich and co… … Medical dictionary
arsphenamine — n. drug formerly used to fight syphilis … English contemporary dictionary
arsphenamine — [α:s fɛnəmi:n, ɪn] noun Medicine a synthetic organic arsenic compound formerly used to treat syphilis … English new terms dictionary
arsphenamine — ars·phen·a·mine … English syllables
