Lansoprazole
- Lansoprazole
-
| Lansoprazole |
 |
| Général |
| Nom IUPAC |
(RS)-2-([3-méthyl-4-(2,2,2-trifluoroéthoxy)pyridin-2-yl]méthylsulfinyl)-1H-benzo[d]imidazole |
| No CAS |
103577-45-3 |
| Code ATC |
A02BC03 |
| DrugBank |
APRD00077 |
| PubChem |
3883 |
| Propriétés chimiques |
| Formule brute |
C16H14F3N3O2S [Isomères]
|
| Masse molaire[1] |
369,361 ± 0,02 g·mol-1
C 52,03 %, H 3,82 %, F 15,43 %, N 11,38 %, O 8,66 %, S 8,68 %,
|
| Données pharmacocinétiques |
| Biodisponibilité |
80% ou plus |
| Liaison protéique |
97% |
| Métabolisme |
hépatique (CYP3A4 et assisté par CYP2C19) |
| Demi-vie d’élim. |
1 à 1H30 |
| Excrétion |
rénale et fécale |
|
Unités du SI & CNTP, sauf indication contraire.
|
Le lanzoprazole est un antisécrétoire gastrique inhibiteur de la pompe à protons commercialisé sous le nom de LANZOR et OGAST.
Indications
- Ulcère duodénal ;
- Œsophagite par reflux gastro-œsophagien ;
- Syndrome de Zollinger-Ellison.
Contre-indication
Avec l'atazanavir, il convient de diminuer l'absorption de ce dernier.
Notes et références
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Contenu soumis à la licence CC-BY-SA. Source : Article Lansoprazole de Wikipédia en français (auteurs)
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