Aprépitant
- Aprépitant
-
| Aprépitant |
 |
| Général |
| Nom IUPAC |
5-([(2R,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluorophenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one |
| No CAS |
170729-80-3 |
| Code ATC |
A04AD12 |
| DrugBank |
APRD00100 |
| PubChem |
151165 |
| Propriétés chimiques |
| Formule brute |
C23H21F7N4O3 [Isomères]
|
| Masse molaire[1] |
534,4267 ± 0,0216 g·mol-1
C 51,69 %, H 3,96 %, F 24,88 %, N 10,48 %, O 8,98 %,
|
| Données pharmacocinétiques |
| Biodisponibilité |
60-65% |
| Liaison protéique |
>95% |
| Métabolisme |
Hépatique (mostly CYP3A4- mediated) |
| Demi-vie d’élim. |
9-13 heures |
|
Unités du SI & CNTP, sauf indication contraire.
|
L'aprépitant est un médicament appartenant à la classe antagonistes de la substance P. Il agit sur les récepteurs NK1 (récepteurs des tachykinines).
Il est utilisé comme antiémétique, dans la prévention des nausées-vomissements dus aux chimiothérapies émétisantes.
Notes et références
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Contenu soumis à la licence CC-BY-SA. Source : Article Aprépitant de Wikipédia en français (auteurs)
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Aprepitant — drugbox IUPAC name = 5 [(2 S ,3 R ) 2 [(1 R ) 1 [3,5 bis(trifluoromethyl)phenyl] ethoxy] 3 (4 fluorophenyl)morpholin 4 yl] methyl] 1,2 dihydro 1,2,4 triazol 3 one CAS number = 170729 80 3 ATC prefix = A04 ATC suffix = AD12 ATC supplemental =… … Wikipedia
Aprepitant — Strukturformel Allgemeines Freiname Aprepitant Andere Namen … Deutsch Wikipedia
aprepitant — noun An antagonist]] drug]], 5 (2S,3R) 2 [(1R) 1 [3,5 bis(trifluoromethyl)phenyl] ethoxy] 3 (4 fluorophenyl)morpholin 4 yl] methyl] 1,2 dihydro 1,2,4 triazol 3 one, used to prevent nausea]] following chemotherapy]] … Wiktionary
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170729-80-3 — Aprépitant Aprépitant Général Nom IUPAC 5 ([(2R,3S) 2 ((R) 1 [3,5 bis(trifluoromethyl)phenyl]ethoxy) 3 (4 fluorophenyl)morpholino]methyl) 1H 1,2,4 triazol 3(2H) one … Wikipédia en Français
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