Kétoconazole
- Kétoconazole
-
| Kétoconazole |
 |
| Général |
| Nom IUPAC |
1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophényl)-2-(1H-imidazol-1-ylméthyl)-1,3-dioxolan-4-yl]méthoxy}phényl)pipérazin-1-yl]éthan-1-one |
| No CAS |
65277-42-1 |
| Code ATC |
J02AB02 |
| DrugBank |
APRD00401 |
| PubChem |
47576 |
| SMILES |
CC(=O)N1CCN(CC1)c2ccc(cc2)OC[C@H]4CO[C@@](Cn3cncc3)(O4)c5ccc(Cl)cc5Cl
PubChem, Vue 3D
|
| InChI |
InChI : Vue 3D
InChI=1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
|
| Propriétés chimiques |
| Formule brute |
C26H28Cl2N4O4 [Isomères]
|
| Masse molaire[1] |
531,431 ± 0,029 g·mol-1
C 58,76 %, H 5,31 %, Cl 13,34 %, N 10,54 %, O 12,04 %,
|
| Données pharmacocinétiques |
| Biodisponibilité |
variable |
| Liaison protéique |
84 à 99% |
| Métabolisme |
hépatique |
| Demi-vie d’élim. |
en deux phases
- phase initiale: 2 heures
- phase terminale: 8 heures
|
| Excrétion |
biliaire et rénal |
|
Unités du SI & CNTP, sauf indication contraire.
|
Le kétoconazole est un antifongique.
Mode d'action
Le kétoconazole inhibe la synthèse de l'ergostérol, molécule constitutive de la membrane fongique.
Spécialités contenant du kétoconazole
Notes et références
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Contenu soumis à la licence CC-BY-SA. Source : Article Kétoconazole de Wikipédia en français (auteurs)
Regardez d'autres dictionnaires:
Ketoconazole — Systematic (IUPAC) name 1 [4 (4 {[(2R,4 … Wikipedia
Ketoconazole — КЕТОКОНАЗОЛ ( Ketoconazole ). 1 цис 1 Ацетил 4 пара n [2 (2,4 дихлофенил) 2 (имидазол 1 илметил) 1,3 диоксолан 4 ил) метоксифенил пиперазин. Синонимы: Низорал, Ороназол, Candoral, Cetonax, Fungocin, Fungoral, Ketonil, Ketozol, Micosept, Orifungal … Словарь медицинских препаратов
ketoconazole — noun Etymology: ket + conazole (as in miconazole) Date: 1979 a synthetic broad spectrum antifungal agent C26H28Cl2N4O4 used to treat chronic internal and cutaneous infections … New Collegiate Dictionary
ketoconazole — /kee toh koh neuh zohl , zawl /, n. Pharm. a synthetic substance, C26H28Cl2N4O4, used to treat a variety of fungal infections. [KETO + con of uncert. derivation + AZOLE] * * * … Universalium
ketoconazole — noun A synthetic antifungal drug used especially in immunocompromised patients … Wiktionary
ketoconazole — A broad spectrum antifungal agent used to treat systemic and topical fungal infections. * * * ke·to·co·na·zole .kē tō kō nə .zōl n a synthetic broad spectrum antifungal agent C26H28Cl2N4O4 used to treat chronic internal and cutaneous disorders … Medical dictionary
ketoconazole — ke·to·co·na·zole … English syllables
ketoconazole — n. an antifungal drug (see imidazole) used in the treatment of such fungal diseases as candidosis, histoplasmosis, and blastomycosis that are resistant to other antifungals. It is taken by mouth; side effects include dizziness, drowsiness, nausea … The new mediacal dictionary
ketoconazole — A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones … English dictionary of cancer terms
ketoconazole — ˌkēd.ōˈkōnəˌzōl noun ( s) Etymology: ket + conazole (as in miconazole herein : a synthetic broad spectrum antifungal agent C26H28Cl2N4O4 used to treat chronic internal and cutaneous infections * * * /kee toh koh neuh zohl , zawl /, n. Pharm. a… … Useful english dictionary
