- Génomique comparative
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La génomique comparative est l'étude comparative de la structure et fonction des génomes de différentes espèces. Elle permet d'identifier et de comprendre les effets de la sélection sur l'organisation et l'évolution des génomes. Ce nouvel axe de recherche bénéficie de l'augmentation du nombre de génomes séquencés et de la puissance des outils informatiques. Une des applications majeures de la génomique comparative est la découverte de gènes et de leurs séquences régulatrices non-codantes basée sur le principe de conservation.
Sommaire
Voir aussi
Références
Further reading
- Kellis M, Patterson N, Endrizzi M, Birren B, Lander E (2003). Sequencing and Comparison of yeast species to identify genes and regulatory elements. Nature, pp. 241–254 (15 May 2003).
- Cliften P, Sudarsanam P, Desikan A (2003). Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science, pp. 71–76 (4 July 2003).
- Hardison RC. (2003). Comparative genomics. PLoS biology, 1(2):e58.
- Stein LD, et al. (2003). The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biology, 1(2):E45. doi: 10.1371/journal.pbio.0000045
- Boffeli D, McAuliffe J, Ovcharenko D, Lewis KD, Ovcharenko I, Pachter L, Rubin EM (2003). Phylogenetic shadowing of primate sequences to find functional regions of the human genome, Science, 299(5611):1391-1394.
- Dujon B, et al. (2004). Genome evolution in yeasts. Nature, 430:35-44 (1 July 2004).
- Filipski A, Kumar S (2005). Comparative genomics in eukaryotes. In The Evolution of the Genome (ed. T.R. Gregory), pp. 521–583. Elsevier, San Diego.
- Gregory TR, DeSalle R (2005). Comparative genomics in prokaryotes. In The Evolution of the Genome (ed. T.R. Gregory), pp. 585–675. Elsevier, San Diego.
- Xie X, Lu J. Kulbokas EJ, Golub T, Mootha V, Lindblad-Toh K, Lander E, Kellis M (2005). Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature.
- Champ PC, Binnewies TT, Nielsen N, Zinman G, Kiil K, Wu H, Bohlin J, Ussery DW (2006). Genome update: purine strand bias in 280 bacterial chromosomes. Microbiology, 152(3):579-583. HubMed
Liens externes
- Genomes OnLine Database (GOLD)
- Genome News Network
- JCVI Comprehensive Microbial Resource
- Pathema: A Clade Specific Bioinformatics Resource Center
- CBS Genome Atlas Database
- The UCSC Genome Browser
- The U.S. National Human Genome Research Institute
- Ensembl The Ensembl Genome Browser
- Genolevures, comparative genomics of the Hemiascomycetous yeasts
- Phylogenetically Inferred Groups (PhIGs), a recently developed method incorporates phylogenetic signals in building gene clusters for use in comparative genomics.
- Metazome, a resource for the phylogenomic exploration and analysis of Metazoan gene families.
- IMG The Integrated Microbial Genomes system, for comparative genome analysis by the DOE-JGI.
- Dcode.org Dcode.org Comparative Genomics Center.
- SUPERFAMILY Protein annotations for all completely sequenced organisms
- Portail de la biologie cellulaire et moléculaire
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