Fatty acid synthase
- Fatty acid synthase
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Acide gras synthase
L'Acide gras synthase est un complexe multienzymatique (dimère d'enzymes sous forme antiparallèles dépendant de l'acide pantothénique et du Coenzyme A), aussi connu sous le nom de FAS (Fatty Acid Synthase). Il est formé par 2 protomères dont la liaison se fait, et est facilitée lorsque la cellule présente un taux de élevé de fructose 1,6-diphosphate (indiquant un état de haute énergie cellulaire puisque c’est un produit intermédiaire de la glycolyse). Elle forme les acides gras à partir de malonyl-CoA
L’Acide Gras Synthase fonctionne avec 2 coenzymes :
- La 4-phosphopantéthéine (constituée d’une structure similaire au fragment non nucléotidique du Coenzyme A).
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Catégories : Lipide | Enzyme
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Fatty acid synthase — (FAS) is enzymatic system composed of 272 kDa multifunctional polypeptide, in which substrates are handed from one functional domain to the next [Alberts, A.W., Strauss, A.W., Hennessy, S. Vagelos, P.R. Regulation of synthesis of hepatic fatty… … Wikipedia
Fatty-acid synthase — In enzymology, a fatty acid synthase (EC number|2.3.1.85) is an enzyme that catalyzes the chemical reaction:acetyl CoA + n malonyl CoA + 2n NADPH + 2n H+ ightleftharpoons a long chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+The 4 substrates of… … Wikipedia
fatty-acid synthase — fat·ty ac·id syn·thase (fatґe asґid sinґthās) [EC 2.3.1.85] an enzyme complex that catalyzes the synthesis of long chain fatty acids. Two carbon units are successively added to the growing chain in a process similar to fatty acid oxidation… … Medical dictionary
Fatty acid metabolism — Fatty acids are an important source of energy for many organisms. Excess glucose can be stored efficiently as fat. Triglycerides yield more than twice as much energy for the same mass as do carbohydrates or proteins. All cell membranes are built… … Wikipedia
Fatty acid synthesis — Fatty acids are formed by the action of Fatty acid synthases from acetyl CoA and malonyl CoA precursors. De Novo Synthesis in HumansIn humans fatty acids are predominantly formed in the liver and adipose tissue, and mammary glands during… … Wikipedia
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Essential fatty acid — Essential fatty acids, or EFAs, are fatty acids that cannot be constructed within an organism from other components (generally all references are to humans) by any known chemical pathways; and therefore mustbe obtained from the diet. The term… … Wikipedia
Delta12-fatty acid dehydrogenase — Identifiers EC number 1.14.99.33 Databases IntEnz IntEnz vi … Wikipedia
Fatty-acyl-CoA synthase — In enzymology, a fatty acyl CoA synthase (EC number|2.3.1.86) is an enzyme that catalyzes the chemical reaction:acetyl CoA + n malonyl CoA + 2n NADH + 2n NADPH + 4n H+ ightleftharpoons long chain acyl CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+The 3 … Wikipedia
