Transcription Start Site
- Transcription Start Site
-
Site d'initiation de la transcription
Pour les articles homonymes, voir
TSS.
Le site d'initiation de la transcription (Transcription Start Site, TSS en Anglais) est le premier nucléotide de l'ADN qui est transcrit en ARN.
Identification du site d'initiation de la transcription
Le TSS ne correspond pas au premier acide aminé de la protéine correspondante (si cet ARN est traduit). Il est difficile de déterminer sa position exacte par bioinformatique, mais il existe plusieurs méthodes expérimentales pour le localiser :
- l'extension d'amorce,
- la cartographie à la nucléase,
- le CAGE ou Cap Analysis of Gene Expression (identification du "cap" - début d'un ARN messager - par analyse de l'expression génique),
Catégorie : Biologie moléculaire
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Contenu soumis à la licence CC-BY-SA. Source : Article Transcription Start Site de Wikipédia en français (auteurs)
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