Enzyme glucuronosyltransférase
- Enzyme glucuronosyltransférase
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Glucuronyltransférase
La glucuronyltransférase est une enzyme détoxifiante se situant dans le tissu hépatique. Elle sert principalement à la transformation de la bilirubine non conjuguée (ou libre) en bilirubine conjuguée.
Pathologie
Le déficit en enzyme glucuronyltransférase est responsable de troubles variant selon son importance. Le déficit partiel conduit à la maladie de Gilbert et un déficit total à la maladie de Crigler-Najjar.
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Glucuronosyltransferase — Protein Name=PAGENAME caption= Symbol=UGT1A1 AltSymbols= HGNCid=12530 Chromosome=2 Arm=q Band=37 LocusSupplementaryData= ECnumber=2.4.1.17 OMIM=191740 EntrezGene=54658 RefSeq=NM 000463 UniProt=P22309 PDB=Uridine 5 diphospho… … Wikipedia
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