Vernakalant
- Vernakalant
-
Le vernakalant est une molécule, testé en tant que médicament antiarythmique dans la régularisation de la fibrillation auriculaire.
Mécanisme
Cette molécule bloque les canaux ioniques potassiques[1].
Efficacité
Il permet, en injection, de régulariser le rythme cardiaque des patients ayant passé récemment en fibrillation auriculaire dans environ la moitié des cas[2]. Il s'avère être d'une efficacité supérieure à celle de l'amiodarone chez ce type de patient[3].
Notes et références
- ↑ Fedida D, Orth PM, Chen JY et al. The mechanism of atrial antiarrhythmic action of RSD1235, J Cardiovasc Electrophysiol, 2005;16:1227–38
- ↑ Stiell IG, Roos JS, Kavanagh KM et al. A multicenter, open-label study of vernakalant for the conversion of atrial fibrillation to sinus rhythm, Am Heart J, 2010;159:1095–10
- ↑ Camm AJ, Capucci A, Hohnloser SH et al. A randomized active-controlled study comparing the efficacy and safety of vernakalant to amiodarone in recent-onset atrial fibrillation, J Am Coll Cardiol, 2011;57:313–21
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