Matrix Attachment Regions
- Matrix Attachment Regions
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Les MARs ou Matrix Attachment Regions sont des séquences d’ADN eucaryote associées à la matrice nucléaire pendant l’interphase [1]. Ces éléments jouent un rôle dans la structure de la chromatine[2],[3], en organisant le génome des cellules eucaryotes en boucles indépendantes de chromatine[4]. Une telle ségrégation de la chromatine permet de former des régions d’ADN décompacté, plus accessible à la machinerie de transcription[5].
Notes et références
- ↑ Hart C, Laemmli U. 1998. Facilitation of chromatin dynamics by SARs. Curr Opin Genet Dev 8 : 519-525.
- ↑ Mirkovitch J, Mirault ME, Laemmli UK. Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold. Cell. 1984 Nov;39(1):223-32.
- ↑ Breyne P, Marc van Montagu and Godelieve Gheysen. The role of scaffold attachment regions in the structural and functional organization of plant chromatin. Transgenic Reseach. 1994
- ↑ Heng HH, Krawetz SA, Lu W, Bremer S, Liu G, Ye CJ. Re-defining the chromatin loop domain. Cytogenet Cell Genet. 2001;93(3-4):155-61.
- ↑ Ruh MF, Dunn R 2nd, Ruh TS. Interrelationships between nuclear structure and ligandactivated intracellular receptors. Crit Rev Eukaryot Gene Expr. 1996;6(2-3):271-83.
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