Thréonine ammonia-lyase

Thréonine ammonia-lyase
Thréonine ammonia-lyase
  N° EC   EC 4.3.1.19
  N° CAS   774231-81-1
  Bases de données
  IntEnz   Vue IntEnz
  BRENDA   Entrée BRENDA
  IUBMB   4.3.1.19 à l'IUBMB
  KEGG   Entrée KEGG
  MetaCyc   Voie métabolique
  PRIAM   Profil
  PDB   Structures
  GO   AmiGO / EGO

La thréonine ammonia-lyase, appelée aussi thréonine déhydratase est une enzyme impliquée dans la voie de biosynthèse de l'isoleucine. Elle catalyse la réaction suivante :

L-thréonine \begin{smallmatrix}\rightleftharpoons\end{smallmatrix} 2-oxobutanoate + NH3

Une forme modifiée est aujourd'hui utilisée afin de produire la L-isoleucine en grande quantité, grâce à la modification d'un site allostérique.

Source

  • Publication N°.: WO/1995/019442

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