Bortézomib
- Bortézomib
-
| Bortézomib |
 |
| Général |
| Nom IUPAC |
acide [(1R)-3-méthyl-1-[[(2S)-3-phényl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronique |
| No CAS |
179324-69-7 |
| DrugBank |
DB00188 |
| PubChem |
387447 |
| SMILES |
B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
PubChem, Vue 3D
|
| InChI |
InChI : Vue 3D
InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
|
| Propriétés chimiques |
| Formule brute |
C19H25BN4O4 [Isomères]
|
| Masse molaire[1] |
384,237 ± 0,026 g·mol-1
C 59,39 %, H 6,56 %, B 2,81 %, N 14,58 %, O 16,66 %,
|
| Données pharmacocinétiques |
| Biodisponibilité |
n/a |
| Liaison protéique |
83% |
| Métabolisme |
hépatique |
| Demi-vie d’élim. |
9 à 15 heures |
|
Unités du SI & CNTP, sauf indication contraire.
|
Le bortézomib est une molécule anticancéreuse inhibant le protéasome commercialisée sous le nom de Velcade pour traiter le myélome multiple.
Notes et références
Wikimedia Foundation.
2010.
Contenu soumis à la licence CC-BY-SA. Source : Article Bortézomib de Wikipédia en français (auteurs)
Regardez d'autres dictionnaires:
Bortezomib — Strukturformel Allgemeines Freiname Bortezomib Andere Namen … Deutsch Wikipedia
Bortezomib — Drugbox IUPAC name = [(1 R ) 3 methyl 1 [(2 S ) 1 oxo 3 phenyl 2 [(pyrazinylcarbonyl)amino] propyl] amino] butyl] boronic acid CAS number = 179324 69 7 ATC prefix = L01 ATC suffix = XX32 PubChem = 93860 DrugBank = APRD00828 C=19 | H=25 | B=1 |… … Wikipedia
bortezomib — A drug used to treat multiple myeloma that has gotten worse during treatment with other anticancer drugs. It is also used to treat mantle cell lymphoma in patients who have already received at least one other type of treatment. Bortezomib is also … English dictionary of cancer terms
bortezomib — noun A particular drug used in chemotherapy … Wiktionary
bortezomib — bor·tez·o·mib (bor tezґə mib) a proteasome inhibitor with antineoplastic activity, used in treatment of multiple myeloma and mantle cell lymphoma; administered by intravenous injection … Medical dictionary
bortezomib — n. a cytotoxic drug that works by inhibiting proteasomes and causing death of malignant cells. It is administered intravenously in the treatment of myeloma. Side effects include peripheral neuropathy, thrombocytopenia, and nausea. Trade names:… … The new mediacal dictionary
PS-341 — Strukturformel Allgemeines Freiname Bortezomib Andere Namen (1R) 3 Methyl 1 [((2R … Deutsch Wikipedia
Velcade — Strukturformel Allgemeines Freiname Bortezomib Andere Namen (1R) … Deutsch Wikipedia
Multiple myeloma — Classification and external resources Micrograph of a plasmacytoma, the histologic correlate of multiple myeloma. H E stain ICD … Wikipedia
Proteasoma — Saltar a navegación, búsqueda Modelo estructural de un proteasoma. Los sitios activos se encuentran dentro del tubo azul. Los extremos rojos regulan la entrada de la proteína al tubo donde será degradada … Wikipedia Español
